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Birkin had suffered a mild stroke in 2021, but the official cause of death has not been announced.
Birkin first found prominence following her move to Paris from her native London when she was 20.
Birkin and Gainsbourgs tumultuous relationship was the subject of international fascination.
They would go on to have a daughter together, the singer, actor, and directorCharlotte Gainsbourg.
Though they broke up in 1981, they would remain friends until Gainsbourgs death on 1991.
The Birkin bag, which debuted in 1984, became one of the worlds most coveted accessories.
Birkin, an outspoken advocate for women and LGBTQ rights, was beloved in her adopted home of France.
The most Parisian of the English has left us, Pariss mayor Anne Hidalgo tweeted.
We will never forget her songs, her laughs and her incomparable accent which have always accompanied us.