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Applegate was diagnosed withmultiple sclerosis in 2021while filming the third and final season of the show.

The powers that be were like, Lets just stop.
We dont need to finish it.
Lets put a few episodes together, she told the New YorkTimesof her diagnosis during production.
I said, No.
Were going to do it, but were going to do it on my terms.
Applegate toldVanity Fairthat though she wont be doing on-camera work, shes open to voice-over acting.
I cant even imagine going to set right now.
This is a progressive disease.
I dont know if Im going to get worse.